What is Dermamelan®?

Dermamelan® is a unique medical depigmentation method with proven efficacy for treating extreme and skin hyperpigmentations resistant to other treatment methods. Its dual action is able to correct visible hyperpigmentations and regulate melanin overproduction, to provide a short and long-term result with the outcome being clear and blemish-reduced skin.

There has been multiple clinical studies and thousands of patients and specialists all over the world that support the efficacy and safety of Dermamelan for the treatment of all types of skin hyperpigmentations and phototypes.

What is hyperpigmentation caused from?

Skin hyperpigmentation is a common problem especially in the Australian sunny climate and affects all skin types and colours. Other than ultra-violet sun exposure hyperpigmentation is also triggered by numerous internal and other external factors such as:

  • Genetic predisposition
  • Hormonal fluctuations
  • Ageing
  • Inflammation due to skin conditions like acne
  • Exposure to certain chemicals
  • Photosensitising medication
  • Trauma

Your Dermamelan experience


Dermamelan can effectively treat various kinds of hyperpigmentation such as:

  • Melasma
  • Post-inflammatory hyperpigmentation
  • Freckles or ephelides
  • Sun spots or solar lentigines

The Dermamelan difference

Our Dermamelan treatment provides an intensive corrective action on skin hyperpigmentation while regulating the overproduction of melanin by inhibiting and controlling the reoccurrence of new spots.

It provides long term results by regulating production of excessive pigmentation and short term corrective results by speeding up the skin renewal process, forcing skin shedding and removing melanin deposits.


Results are best seen at 1 to 3 months after your Dermamelan treatment. With ongoing maintenance and follow up with our Dermal Practitioner you will be able to notice an overall improvement with your skin

You can expect to see:

  • Significant reduction of hyperpigmentation
  • Improvement of skin texture
  • Improvement of skin tone

View our Dermamelan treatment experience with Before & After photos.


What to expect


Dermamelan is an advanced cosmetic procedure performed by our Dermal Practitioner within our Doctor-led clinic, so a consultation is essential to assess your suitability and understand your desired outcomes. If your skin is deemed unsuitable for this depigmentation treatment, alternative options will be recommended to you.

Pre-treatment preparation

Our Dermal Practitioner will explain how to prepare your skin during your consultation.


Dermamelan is a two-phase treatment. The initial part takes place in our clinic, where our Dermal Practitioner will apply the treatment mask to the area of skin being treated. This needs to remain in place for 8 to 12 hours, depending on your skin type and the severity of your pigmentation. It’s advisable that you book your Dermamelan treatment in the morning, so that once it’s applied you can go home and wash it off just before bedtime.

Phase-two is an at home maintenance program. It comprises of 7 full sized Mesoestetic skincare products that are included in the treatment cost. These must be exclusively used for at least 12 weeks post phase-one. A skin reassessment will occur at this point, where you’ll see your before and after depigmentation images and have a personalised ongoing skincare routine prescribed by our Dermal Practitioner.

Post treatment

Redness is evident immediately after washing off the depigmentation mask and can persist for up to 4 weeks. It generally starts to subside from day two onwards.

Pigmentation will become darker as it’s pushed towards the surface of your skin before shedding. This can last until the peeling has finished, which usually takes around two weeks.

Skin peeling and dryness will occur as the old skin is pushed to the surface and your new skin is revealed. The shedding usually starts from the centre of your face and graduates towards the perimeter. The parts of your expression that move a lot (like around your mouth), will peel faster and more excessively. Optimal results will be achieved when you allow the skin to shed naturally.

Skin sensitivity may increase due to the intensity of the depigmentation treatment causing a temporary impairment to the barrier of your skin. You may feel mild burning or tingling when applying your skin care products which usually subsides after a few minutes.

You’ll be invited to come into our clinic to enjoy 3 complimentary LED Healite sessions at days 2, 6 and 14 (subject to change based on each individuals healing times) after the phase-one appointment to aid your healing and promote optimal results.

Comprehensive post care guidelines will be given to you, so you can refer to them at home.

How long will my Dermamelan results last?

Our Dermamelan treatment provides an intensive corrective action on skin pigmentation and hyperpigmentation, while simultaneously regulating the overproduction of melanin by inhibiting and controlling the reoccurrence of new spots. It provides short term corrective results by speeding up the skin renewal process, forcing skin shedding which removes melanin deposits, and long-term results by regulating the production of pigmentation.

Am I suitable for Dermamelan?

If hyperpigmentation such as age spots, sun spots, post inflammatory marks or melasma if a concern then you are most likely suitable to Dermamelan.

Unlike lasers we are not restricted to particular skin types when treating with Dermamelan making the treatment safe and effective for nearly everyone.

If you are looking for complete removal of pigmentation and permanent results, as well as a no downtime treatment then you may not be suited to Dermamelan.

What is the difference between the Dermamelan and Cosmelan treatment?

Dermamelan is a medical-grade treatment that can safely and effectively reach deep set pigmentation and can only be performed within doctor-led clinics. It is is 30% stronger than Cosmelan treatment and is the preferred treatment for melasma and darker fitzpatrick skin types.

Cosmelan is suitable for superficial pigmentation such as freckles and sunspots that can be administered without doctor supervision and suitable for mild pigmentation.

Click here to view a Dermamelan journey, documented in daily diary form, including images before the depigmentation process through to 6 weeks post treatment.

Get in Touch

Interested in Dermamelan depigmentation treatment?

We welcome you to Pavilion Cosmetic Medicine Sydney for a consultation with our cosmetic practitioners, who'll tailor a treatment plan specific to your concerns and desires.

Enquire now
Got questions?

We're here to help

Not ready to book? Still have questions? Leave us a message and we will get back to you as soon as possible.